10:00

Caractérisation anatomopathologique des adénomes gonadotropes
Pathological characterisation of gonadotroph adenomas

Alexandre VASILJEVIC
10:25

Caractérisation moléculaire des adénomes gonadotropes
Molecular characterisation of gonadotroph adenomas

Guillaume ASSIE
10:50

Histoire naturelle des adénomes gonadotropes
Natural history of gonadotroph adenomas

Dominique MAITER
11:15

Faut-il irradier les adénomes gonadotropes?
Should gonadotroph adenomas be irradiated?

Philippe CHANSON
11:40

Adénomes gonadotropes cliniquement fonctionnels
Clinically functioning gonadotroph adenomas

Niki KARAVITAKI
12:05

Faut-il traiter médialement les adénomes gonadotropes ?
Should gonadotroph adenomas be treated medically?

Frédéric CASTINETTI
12:30

Conclusion
Conclusion

Chairs : Ilan SHIMON (ISRAEL), Albert BECKERS (BELGIUM)

13:15

AIP as a Co-Chaperone: A Finger in every Pie

Marta KORBONITS (UNITED KINGDOM)

Chairs : Giovanna MANTOVANI (ITALY), Nicolas DE ROUX (FRANCE)

14:00

Sleep & energy balance

Peter LIU (UNITED STATES)
14:20

Circadian clock and insulin resistance

Andries KARLSBEEK (NETHERLANDS)
14:40

Pacing the glucocorticoids

Chiara SIMEOLI (ITALY)

Chairs : Monica GADELHA (BRAZIL), Philippe CHANSON (FRANCE)

15:30

Precision medicine in the treatment of acromegaly

Jens BOLLERSLEV (NORWAY)
15:50

Paradoxical GH increase during OGTT & its implications in managing acromegaly

Dominique MAITER (BELGIUM)
16:10

Acromegaly in the elderly patients

Sabrina CHILOIRO (ITALY)
16:30

Short presentation: FTO polymorphisms & cardiovascular comorbidities

Aleksandra JAWIARCZYK-PRZYBYŁOWSKA (POLAND)

Chairs : Niki KARAVITAKI (UNITED KINGDOM), Thierry BRUE (FRANCE)

16:45

Idiopathic central diabetes insipidus in a large cohort of patients; The hypopituitarism ENEA rare observational (HEROS) study

Hiba Masri Iraqi (ISRAEL)
17:00

Mappy Study - Monitoring of Asymptomatic AIP mutated Pituitar Y patients

Pauline ROMANET (FRANCE)
17:15

MISSION Study - The worldwide most powerful epidemiological study on the complication and the mortality associated with Cushing's syndrome. AMORE Study - Aggressive pituitary tumors: a Multicenter Observational, Retrospective study of ENEA. Epidemiology, clinical profile, and outcomes of patients with prolactinomas taking a high dose cabergoline (≥ 3mg/week): RESISTANT PROLACTINOMA STUDY.

Krystallenia ALEXANDRAKI (GREECE)

Chairs : Niki KARAVITAKI (UNITED KINGDOM), Thierry BRUE (FRANCE)

17:30

European Pituitary Pathology Group: who we are and what is our mission

Chiara VILLA (FRANCE)
08:30

Testing the recovery of the axis in tertiary adrenal insufficiency

Riccardo POFY (ITALY)
08:30

Hypopituitarism and pregnancy

Małgorzata KARBOWNIK-LEWIŃSKA (POLAND)
08:30

Hormone receptor targets in neuroendocrine tumours

Emanuel CHRIST (SWITZERLAND)

Chairs : Maria TICHOMIROWA (LUXEMBOURG), Marek BOLANOWSKI (POLAND)

09:00

The year in neuroendocrinology - basic

Constantine STRATAKIS (GREECE)
09:30

The year in neuroendocrinology - clinical

Vera POPOVIC (SERBIA)

Chairs : Marily THEODOROPOULOU (GERMANY)

10:30

A time to fast, a time to feast: interaction between chronobiological and neuroendocrine systems

Henrik OSTER (GERMANY)

Chairs : Raul LUQUE (SPAIN), Gérald RAVEROT (FRANCE)

11:00

Synaptic communication & reproductive circuits

Patrice MOLLARD (FRANCE)
11:20

Stem cell-derived paracrine signals in pituitary homeostasis

Cynthia ANDONIADOU (UNITED KINGDOM)
11:40

Clinical Imaging of the pituitary stalk

Mohamad MAGHNIE (ITALY)
14:00

New biochemical tools in the diagnosis and follow up of Cushing's disease

Martin BIDLINGMAIER
14:00

Clinical management of MEN 1

Maria Luisa BRANDI
14:00

Probing genome’s architecture in cell plasticity and disease

Martin FRANKE (SPAIN)

Chairs : Pedro MARQUES (PORTUGAL), Juan Manuel JIMÉNEZ VACAS (UNITED KINGDOM)

14:30abstract

Molecular mechanisms of cavernous sinus invasion by pituitary adenomas: in vitro studies and in vivo investigations in a rat model of invasive pituitary tumorigenesis obtained by stereotactic pituitary GC cells injection

Michael BUCHFELDER (GERMANY)
14:39abstract

Circulating microRNAs as predictors for dopamine agonists in hyperprolactinemic patients with pituitary adenoma

Jae Won HONG (KOREA, REPUBLIC OF)
14:48abstract

Effect of a novel somatostatin receptor 5/3 agonist, HTL0030310, on human GH- and ACTH-secreting pituitary adenomas in vitro  

Daniela REGAZZO (ITALY)
14:57abstract

Xq26.3 duplications in X-linked acrogigantism (X-LAG) disrupt a topologically associating domain (TAD) and rewire GPR101-enhancer interactions

Giampaolo TRIVELLIN (ITALY)

Morphological and molecular evidence of macroautophagy in pituitary tumors

Laura CECENARRO (ARGENTINA)

New provocation test using MDMA (‘Ecstasy’) demonstrates Oxytocin deficiency in patients with central diabetes insipidus

Cihan ATILA (SWITZERLAND)
15:24abstract

Association between use of systemic and inhaled glucocorticoids and changes in brain volume and white matter microstructure: a cross-sectional UK Biobank study

Merel VAN DER MEULEN (NETHERLANDS)

CRN04894: an oral, nonpeptide ACTH (MC2) receptor antagonist decreaseds basal and stimulated cortisol secretion in healthy volunteers 

Peter TRAINER (UNITED STATES)

Chairs : Juan Pedro MARTINEZ-BARBERA (UNITED KINGDOM)

16:15

The molecular design of hypothalamus development

Marco BENEVENTO (AUSTRIA)
16:35

Pull your SOXs up! - From stem cells to pituitary tumors

Karine RIZZOTI (UNITED KINGDOM)

Chairs : Giampaolo TRIVELLIN (ITALY), Luis G. PÉREZ-RIVAS (GERMANY)

16:55

The Molecular Basis of Congenital Hypopituitarism

Louise C. GREGORY (UNITED KINGDOM)
17:15

Dysregulated peptide amidation as a new cause of hypopituitarism

Elisa ARALDI (SWITZERLAND)
17:35

Human iPS cells as model for congenital hypopituitarism

Thi Thom MAC (FRANCE)

Efficacy and predictive factors of response to immunotherapy in pituitary carcinomas and aggressive pituitary tumors: a French cohort study

Mirela-Diana ILIE (FRANCE)

High prevalence of genetic predisposition in young men and women with lactotrop macroadenomas

Pauline ROMANET (FRANCE)

Prolactinomas: resistance assessment via metabolomic characteristics

Aleksandra SHUTOVA (RUSSIAN FEDERATION)

Impact of the diagnostic delay of acromegaly on bone health: data from a real life and long term follow-up experience

Miriam VELENO (ITALY)

Clinical and translational evidence of metformin and simvastatin additive antitumor effects in glioblastoma via senescence-state

Miguel E G-GARCIA (SPAIN)

Somatic hotspot variants rarely coexist with germline drivers of Cushing’s disease

Laura C. HERNÁNDEZ-RAMÍREZ (MEXICO)

Clinicopathological characteristics, clinical outcome, and prognostic factors for pituitary carcinomas: lessons from a systematic review of 207 cases

Perrine RAYMOND (FRANCE)

Dissecting the in vitro efficacy of octreotide and cabergoline in GH- and GH/PRL-secreting pituitary tumors

Federico GATTO (ITALY)

Somatostatin and ghrelin systems characterization and therapeutic potential in liver diseases

Natalia HERMAN-SÁNCHEZ (SPAIN)

Neoadjuvant B-RAF and MEK inhibitor targeted therapy for Adult Papillary Craniopharyngiomas: A new treatment paradigm

Francesco CALVANESE (FRANCE)

Volumetric BMD and bone strength estimates on QCT-based finite element analysis are impaired in patients with Cushing’s syndrome in long-term remission

Maria Sol BATULE NALLIM (SPAIN)

Prevalence of somatic SF3B1 mutations in lactotroph tumours

Julia SIMON (GERMANY)

Lysine demethylase KDM1A and ectopic expression of GIP-receptor in somatotroph adenomas

Fanny CHASSELOUP (FRANCE)

Discrimination of pituitary neuroendocrine tumours by Raman spectroscopy

Michel PILOT (GERMANY)

Central diabetes insipidus from a patients’ perspective: management, psychological co-morbidities and re-naming of the condition

Cihan ATILA (SWITZERLAND)

Circulating miR-28-5p is a potential biomarker of sarcopenia in patients with Cushing’s syndrome in remission

Elena CASADEMUNT (SPAIN)

The effect of glucose dynamics on plasma copeptin levels upon glucagon, arginine, and macimorelin stimulation in healthy adults

Sophie MONNERAT (SWITZERLAND)

Resistance to cabergoline treatment in human primary non-functioning pituitary tumour cells

Federica BEGALLI (UNITED KINGDOM)

Cabergoline add-on therapy in patients with uncontrolled acromegaly under somatostatin analogues – a multicenter, retrospective, cohort study of non-irradiated patients applying current criteria for disease control  

Sandrine A. URWYLER (UNITED KINGDOM)

Chairs : Maria Chiara ZATELLI (ITALY), Andrea ISIDORI (ITALY)

09:00

From the Patient to cell culture and back : personalized drug testing NETs

Natalia PELLEGATA (GERMANY)
09:30

Kisspeptin: puberty and beyond

Manuel TENA-SEMPERE (SPAIN)
10:00

How to manage recurrent nonfunctioning pituitary tumours

Marco LOSA (ITALY)

Chairs : Antoine TABARIN (FRANCE)

10:00

POMC neurons and energy balance: a tale with many twists and surprises

Daniela COTA (FRANCE)

Chairs : Monica MARAZUELA (SPAIN), Marija PFEIFER (SLOVENIA)

11:00

Oxytocin and social behavior

Bice CHINI (ITALY)
11:20

New diagnostic tests in diabetes insipidus

Mirjam CHRIST CRAIN (SWITZERLAND)
11:40

Management of hyponatermia in different clinical scenarios

Chris J. THOMPSON (IRELAND)
12:00

Intraoperative discrimination of tumour and healthy tissue using spectroscopy

Frank HERTEL (GERMANY)
12:00

Cushing's syndrome due to ectopic ACTH secretion

Antoine TABARIN (FRANCE)
12:00

Pituitary tumours in pregnancy

Anton LUGER (AUSTRIA)

Long-term treatment with oral paltusotine for acromegaly: Results from the ACROBAT Advance study 

Harpal RANDEVA (UNITED KINGDOM)

Debio 4126, a new 3-month octreotide formulation, provides sustained release of octreotide, as well as enhanced bioavailability and similar suppression of insulin-like growth factor 1 (IGF-1), compared to monthly Sandostatin LAR in healthy volunteers - interim results

Anne BELLON (SWITZERLAND)

Genetic aspects of adrenal incidentalomas

Gulrukh ALIMOUKHAMEDOVA (UZBEKISTAN)

Outcomes in patients receiving oral octreotide capsules related to time from last somatostatin receptor ligand injection: analysis from the MPOWERED Phase 3 study

Djuro MACUT (SERBIA)

Clinical-imagine asessment of agressive pituitary adenomas

Ozoda AZIMOVA (UZBEKISTAN)

Patterns of somatostatin receptor ligand dosage and titration in patients with acromegaly: a real-world evidence study

Maria FLESERIU (UNITED STATES)

First-generation somatostatin receptor ligands in the treatment of acromegaly: real-world patient journey

Thierry BRUE (FRANCE)

Treatment of hypothalamic obesity with GLP-1 agonists and extreme diet in a patient with hypothalamic inflammatory infiltration

Eva Marie ERFURTH (SWEDEN)

Clinical case of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) with uncertain localization

Ekaterina PIGAROVA (RUSSIAN FEDERATION)

Vanishing pituitary lesion with intermittent central adrenal insufficiency

Monica Livia GHEORGHIU (ROMANIA)

ACROMEGALY DUE TO  A GH-SECRETING PITUITARY ADENOMA IN THE SPHENOID SINUS

Guillermo SERRA SOLER (SPAIN)

Morning and evening concentrations of salivary aldosterone and cortisol throughout the menstrual cycle in healthy women

Daniela JEZOVA (SLOVAKIA)

Observation of bone mineral density in Cushing syndrome

Gulchekhra NARIMOVA (UZBEKISTAN)

The various clinical outcomes of giant prolactinomas in men

Anna BOGUSLAWSKA (POLAND)

The endoscopic endonasal resection of giant pituitary neuroendocrine tumors - case series from the referral pituitary center.

Jacek KUNICKI (POLAND)

Results of surgical treatment of the Rathke cleft cysts with endoscopic endonasal cyts evacualtion – clinical series from pituitary referral center.

Jacek KUNICKI (POLAND)

Impact of the micro nutriments’ deficit on the functional disorders for diabetic menopause women.

Olfa BERRICHE (TUNISIA)

Health-Related Quality of Life Burden in Endogenous Cushing’s Syndrome: A Retrospective Medical Chart Audit Study

Eliza GEER (UNITED STATES)

Gonadotroph Adenomas. A Single-Center Study of 112 cases.

Mariana SOLOVEY (UKRAINE)

Chairs : Leo HOFLAND (NETHERLANDS), Hervé LEFEBVRE (FRANCE)

14:30

Cell- and tissue specificity of gluocorticoids actions.

Onno MEIJER (NETHERLANDS)
14:50

Long-term consequences of hypercortisolism

Rosario PIVONELLO (ITALY)
15:10

Epigenetic modulation by glucocorticoids

Henriette UHLENHAUT (GERMANY)
15:30

Short presentation: Bone consequences of chronic hypercortisolism

Anna BRONA (POLAND)

Chairs : Alexandre VASILJEVIC (FRANCE)

17:15

Imprinting in hypothalamus-pituitary pathology

Marika CHARALAMBOUS (UNITED KINGDOM)
17:35

Non-coding RNAs: mere messengers or causative factors?

Herniett BUTZ (HUNGARY)
17:55

Pituitary tumor microenvironment

Philippe BERTOLINO (FRANCE)

Chairs : Jérôme BERTHERAT (FRANCE), Patrick PETROSSIANS (BELGIUM)

09:00

Nelson's syndrome

Martin REINCKE (GERMANY)
09:30

Recent Consensus in Cushing's syndrome: the clinical agenda

Elena VALASSI (SPAIN)

Chairs : Emmanuel JOUANNEAU (FRANCE), Krystallenia ALEXANDRAKI (GREECE)

10:30

Emerging pharmacological therapies for craniopharyngiomas

Gregory KALTSAS (GREECE)
10:45

Craniopharyngioma: relapse

John APPS (UNITED KINGDOM)
11:00

Surgical indications and limitations for recurrent pituitary tumors & craniopharyngiomas

Jörg FLITSCH (GERMANY)
11:15

Questions

11:30

Update on temozolomide: results of a European Society of Endocrinology (ESE) survey

Pia BURMAN (SWEDEN)
11:45

What is the role of pathology?

Jacqueline TROUILLAS (FRANCE)
12:00

Immunotherapy for aggressive pituitary tumours & carcinomas

Mirela ILIE (FRANCE)