Clinical-imagine asessment of agressive pituitary adenomas

O. Azimova*^a (Dr), Z. Khalimova^a (Prof)

^a RepublicanSpecialized scientific Practical Medical Center of Endocrinology named after Academician Y.K.Turakulov, Tashkent, UZBEKISTAN

* azimova.ozoda26@gmail.com

Aggressive pituitary adenomas (APA) are adenomas that show rapid growth, invasiveness, frequent or multiple relapses, or are resistant to conventional therapies. Clinical-imaging assessment of aggressive pituitary adenomas using the aid plays an important role in early predicting and predicting further disease outcomes and aggressive behavior of adenomas. Purpose of the study was to assess the correlation of neuroimaging data with the hormonal activity of APA. Materials and methods. The study included 74 patients with aggressive pituitary adenomas. The average age of the patients was from 12 to 69. The patients underwent a basal assessment of the level of pituitary hormones: prolactin (PRL), GH( growth hormone), insulin-like growth factor-1 (IGF-1) and blood cortisol by the RIA method, as well as an MRI study. Knop's classification was used to assess the invasion. Results. The results of hormonal research have established that inactive pituitary adenomas prevail among aggressive adenomas. No correlation was found between the hormonal activity of aggressive adenomas and the volume of pituitary adenomas. According to MRI data, it was also found that invasion into the cavernous sinus of the III degree and heterogeneity of the adenoma can become equivalents of aggressiveness. Conclusion. The established patterns determine the need for visualization assessment of aggressive pituitary adenomas and designation of their degree of aggression based on tumor heterogeneity, chiasm compression, hypo- and iso-intensity in T1 mode and hyperintensity in T2 modes.

The author has declared no conflict of interest.