Clinical manifestations of musculoskeletal complications of acromegaly.

Z. Khalimova*^a (Prof), A. Kholikova^a (Dr), S. Safarova^a (Dr), S. Issayeva^a (Dr), D. Savchuk^a (Dr)

^a Scientific Institute of Endocrinology Named After Turakulov, Tashkent, UZBEKISTAN

* zam-nar777@mail.ru

Purpose of the study. To study the clinical manifestations of the musculoskeletal complications (MC) of acromegaly, to improve early diagnosis diseases.

Materials and methods. 150 patients with acromegaly were examined, observed at the RSSP Medical Center of Endocrinology for the period from 2000 to 2020. The age of the patients ranged from 19 to 76. Of these, 65 were men and 85 women. Wherein the duration of the disease ranged from 1 to 23 years.

Results. An analysis of the complaints of our patients showed that most often complaints of violations of the MC are an increase in the size fingers (96.7%), hands (100%) and feet (98.7%) enlargement of the nose, lips (93.3%), changes in facial features (86.7%), swelling of the face and hands (85.3%). More than half patients complained of pain (in the spine (73.3%) and in the knees - 56%, in thigh area -56.7%). All this led to general weakness and a decrease in working capacity (88%). According to the results of the study, more than half of our patients can already be identified by X-ray analysis various MC. Thus, in 92% of patients, deformity of the phalanges of the hands and feet, thickening of the skull bones (92.7%) and signs of osteoporosis of the spine were revealed. (90%); 80% have an expansion of the periarticular space and deformation of the lower jaw, sinus enlargement (84%) and signs of femoral osteoporosis bones (80.7%).

Conclusions: Among the clinical manifestations of complications of the musculoskeletal system in our patients were enlarged hands and feet. (100%), swelling of the joints (93.3%), expansion of the distal phalanges (92%), puffiness of the face (90.6%), prognathism (80%) and diastema (72%), limitation mobility of the knee joints (70%) and polyarthralgia (66%).

X-ray, being one of the available methods for diagnosing MC of acromegaly, allowed detection in 92% of patients of deformity of the phalanges of the hands, feet, thickening skull bones (92.7%) and signs of osteoporosis of the spine (90%); 80% expansion of the periarticular space and deformation of the lower jaw, in sinus enlargement (84%) and signs of femoral osteoporosis (80.7%).

The author has declared no conflict of interest.