A. Alimova*a (Ms), G. Narimovab (Dr), S. Issaevab (Ms)

a Khorezm region Endocrinological dispensary, Khorezm, UZBEKISTAN ; b Republican Center of Endocrinology, Tashkent, UZBEKISTAN

* anoraxonalimova1979@mail.com

Aim. To determine the clinical features of acromegaly in the Khorezm region

Materials and methods. According to the register of the Republic of Uzbekistan, somatotropic pituitary adenomas are 526 patients. Of these, 47 (8.9%) were identified in the Khorezm region (21 (44.7%) men and 26 (55.3%) women). The mean age was 44.8±23.5 years.

Results. The clinical picture of the disease, as follows from the analysis of the submitted questionnaires, was characterized by a variety of manifestations and indirectly indicated the involvement of various organs and systems in the pathological process. Among health complaints, the following prevailed: headache - 89.4%, change in appearance - 87.2%, joint pain - 29.8%, muscle weakness - 56.7%, sweating - 68.1%. The main objective symptoms of the disease were dominated by arterial hypertension (37%), diabetes mellitus (40.4%) and visual disturbances (42.6%). It is interesting to note that visual disturbances, namely narrowing of the visual fields and atrophy of the optic discs, were recorded in patients in the age group from 31 to 40 years with a disease duration of up to 5 years. As the analysis of hormonal parameters (GH, IGF-1) showed, the majority of patients (87.2%) have an active stage of the disease and require special treatment.

Conclusion. With active acromegaly, the clinical picture of the disease is blurred.

The author has declared no conflict of interest.