" Characteristics of the clinical picture of Type III Polyglandular Autoimmune Syndrome ”
G. Negmatova*a (Mrs), Z. Khalimovab (Prof)
a Samarkand State Medical Institute, Samarkand, UZBEKISTAN ; b Republican Specialized Scientific Practical Medical Center of Endocrinology of Public Health Ministry named by acad. Ya.Kh. Turakulov,, Tashkent, UZBEKISTAN
Introduction. Polyglandular autoimmune syndromes (PAS) are multifactorial diseases with at least two coexisting autoimmune-mediated endocrinopathies. PAS show a great heterogeneity of syndromes and manifest sequentially with a large time interval between the occurrence of the first and second glandular autoimmune disease .Polyglandular autoimmune syndrome type III (PZ III) consists of autoimmune thyroid diseases associated with endocrinopathy, except for adrenal insufficiency. This syndrome is associated with organ-specific, non-specific or systemic autoimmune diseases. The frequency of surfactant syndromes in diabetic children is unknown. .
Observation. We evaluated 45 children with type 1 diabetes mellitus .Mean age of patients was 9,3 years-old. Control group constituted by 20 healthy patients with different age. The patients were divided into 3 groups: Group 1 - PAS III A (DM 1 and autoimmune thyroiditis) -25 patients. Group 2 - PAS III C (DM 1 and other autoimmune diseases: celiac disease, psoriasis and vitiligo) - 20 patients. Group 3 - 20 healthy persons.All patients underwent clinical and biochemical evaluations including endocrine check, lipids profile, hormonal profile (insulin, C-peptide, STH, TSH, prolactin, free testosterone, estradiol, progesterone, etc), genitalia ultrasonography, EKG.
Discussion. The study involved 45 patients with type 1 diabetes mellitus (DM1) aged from 1 to 18 years.PAS III was more common in girls than in boys-78.4% vs. 21.6% (p <0.05). PAS III was observed at the age of 1 to 5 years in 66.6% of children; the frequency decreased in subsequent years and consistently increased in adolescence to 22.7%. PAS III A (DM 1 and autoimmune thyroiditis) It was detected in 11.1%, and PASS III C (DM 1 and other autoimmune diseases: celiac disease, psoriasis and vitiligo) - in 3.5% of children. Children with PAS III should be closely monitored as a risk group for the development of other autoimmune diseases.
- Iwona Ben-Skowronek, Aneta Michalczyk, Robert Piekarski, Beata Wysocka-Łukasik, Bożena BaneckaType III Polyglandular Autoimmune Syndromes in children with type 1 diabetes mellitus// Ann Agric Environ Med. 2013;20(1):140-6.
- Kostas Kakleas, Alexandra Soldatou1, Feneli Karachaliou 2, Kyriaki Karavanaki 3Associated autoimmune diseases in children and adolescents with type 1 diabetes mellitus (T1DM)// Autoimmun Rev. 2015 Sep;14(9):781-97. doi: 10.1016/j.autrev.2015.05.002. Epub 2015 May 20.
The author has declared no conflict of interest.