" Characteristics of the clinical picture of Type III Polyglandular Autoimmune Syndrome ” 

G. Negmatova*^a (Mrs), Z. Khalimova^b (Prof)

^a Samarkand State Medical Institute, Samarkand, UZBEKISTAN ; ^b Republican Specialized Scientific Practical Medical Center of Endocrinology of Public Health Ministry named by acad. Ya.Kh. Turakulov,, Tashkent, UZBEKISTAN

* yulduz.urmanova@mail.ru

Introduction. Polyglandular autoimmune syndromes (PAS) are multifactorial diseases with at least two coexisting autoimmune-mediated endocrinopathies. PAS show a great heterogeneity of syndromes and manifest sequentially with a large time interval between the occurrence of the first and second glandular autoimmune disease [1].Polyglandular autoimmune syndrome type III (PZ III) consists of autoimmune thyroid diseases associated with endocrinopathy, except for adrenal insufficiency. This syndrome is associated with organ-specific, non-specific or systemic autoimmune diseases. The frequency of surfactant syndromes in diabetic children is unknown. [2].

Observation. We evaluated 45 children with type 1 diabetes mellitus .Mean age of patients was 9,3 years-old. Control group constituted by 20 healthy patients with different age. The patients were divided into 3 groups: Group 1 - PAS III A (DM 1 and autoimmune thyroiditis) -25 patients. Group 2 - PAS III C (DM 1 and other autoimmune diseases: celiac disease, psoriasis and vitiligo) - 20 patients. Group 3 - 20 healthy persons.All patients underwent clinical and biochemical evaluations including endocrine check, lipids profile, hormonal profile (insulin, C-peptide, STH, TSH, prolactin, free testosterone, estradiol, progesterone, etc), genitalia ultrasonography, EKG.

Discussion. The study involved 45 patients with type 1 diabetes mellitus (DM1) aged from 1 to 18 years.PAS III was more common in girls than in boys-78.4% vs. 21.6% (p <0.05). PAS III was observed at the age of 1 to 5 years in 66.6% of children; the frequency decreased in subsequent years and consistently increased in adolescence to 22.7%. PAS III A (DM 1 and autoimmune thyroiditis) It was detected in 11.1%, and PASS III C (DM 1 and other autoimmune diseases: celiac disease, psoriasis and vitiligo) - in 3.5% of children. Children with PAS III should be closely monitored as a risk group for the development of other autoimmune diseases.

Bibliography

1. Iwona Ben-Skowronek, Aneta Michalczyk, Robert Piekarski, Beata Wysocka-Łukasik, Bożena BaneckaType III Polyglandular Autoimmune Syndromes in children with type 1 diabetes mellitus// Ann Agric Environ Med. 2013;20(1):140-6.
2. Kostas Kakleas, Alexandra Soldatou¹, Feneli Karachaliou ², Kyriaki Karavanaki ³Associated autoimmune diseases in children and adolescents with type 1 diabetes mellitus (T1DM)// Autoimmun Rev. 2015 Sep;14(9):781-97. doi: 10.1016/j.autrev.2015.05.002. Epub 2015 May 20.

The author has declared no conflict of interest.