GDF15 value in predicting cardio-vascular outcomes  in patients with ACTH depended Cushing syndrome in the Republic of Uzbekistan

Z. Khalimova*a (Prof), G. Jabborovaa (Mrs)

a Republican Specialized Scientific Practical Medical Center of Endocrinology of Public Health Ministry named by acad. Ya.Kh. Turakulov,, Tashkent, UZBEKISTAN

* zam-nar777@mail.ru

Introduction. The growth differentiation factor 15 (GDF15) is a proven valuable biomarker of various pathologies, including cancer, type 2 diabetes and cardiovascular diseases. Although the prognostic value of the GDF15 in heart failure is reliable, the biological function of the GDF15 with adverse remodeling of the heart is not fully studied [1], especially with Cushing syndrome. (CS)

Material and methods We conducted an examination of 22 persons with ACTH-dependent СS.(ACTH-DCS) The control group consisted of 10 patients with hypertonic disease (HD),without CS.

The study used clinical and biochemical, hormonal studies ( ACTH, cortisol, GDF-15), functional tests, as well as instrumental (neurophthalmological, radiological - MRI pituitary gland, MSCT of adrenal glands, X-ray absorption densitometry and statistical techniques.

Results In patients with HD, the average GDF15 values were in the range of 200 (662 ± 633) NG/L established that in 12 patients with ACTH-DCS had remission, and in 10 relapses of the disease. A comparison in the blood GDF15 showed that in patients with ACTH-DCS in remission GDF15 was in the range of 270 (840 ± 810) NG/L, and in patients with re-growth of ACTH- DCS-in the range of 569 (1905 ± 2052) NG/L,

Discussion Dr. Waller and colleagues found that patients with GDF-15 level within normal range-below 1200 ng/l-"have a very good forecast for the next 4 years." "However, patients with increased levels have a high risk of death." [2]. Our research confirms these data

Bibliography

  1. .Adela Ramu , Sanjay K Banerjee .GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular Diseases: A Translational Prospective //J Diabetes Res. 2015;2015:490842. doi: 10.1155/2015/490842. Epub 2015 Jul 27. .

2.Gizatulina T P , Martyanova L U, Petelina T I , Zueva E V , et all. [The association of growth differentiation factor 15 (GDF-15) level with extent of left atrial fibrosis in patients with nonvalvular atrial fibrillation]// Kardiologiia. 2020 Oct 14;60(9):22-29. doi: 10.18087/cardio.2020.9.n1144.

The author has declared no conflict of interest.