U. Mirzaeva*a (Dr)

a Tashkent Pediatric medical institute, Tashkent, UZBEKISTAN

* umida_mirzaeva@mail.ru

The COVID-19 pandemic, caused by the SARS-CoV-2 strain of coronavirus, has spread worldwide since December 2019. One of the challenges to stop the pandemic of the disease is the lack of evidence showing effective pharmacological drugs and treatments to reduce the rate of viral infection and mortality from COVID-19 [1].Vitamin D3 is the object of close attention of scientists. Vitamin D3 helps to increase the body's resistance to external negative factors. Its reception is important during seasonal colds, and especially during a pandemic (2). The background to the study of the role of vitamin D3 in COVID-19 was the suggestion that people with low serum vitamin D levels may have a higher risk of contracting COVID-19 or more severe disease (3). This was supported by the results of several meta-analyses demonstrating a reduction in the risk of acute respiratory infections in individuals taking vitamin D. The proposed mechanism is that vitamin D3 can suppress the production of cytokines (IL-2, IL-6, TNFα, etc.) and thereby reduce the intensity of the cytokine storm (4).
Conclusion: An analysis of the literature indicates that vitamin D3 may be an effective, affordable, and well-tolerated treatment for COVID-19, which continues to rise steadily in incidence and for which there is currently no cure. Further research is needed to confirm whether vitamin D3 supplementation at or just before infection can improve or prevent COVID-19.


  1. Cortegiani A., 2020; Goddek S., 2020; Malaguarnera L., 2020
  2. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths, William B. Grant, Henry Lahore, Sharon L. McDonnell, Carole A. Baggerly, Christine B. French, Jennifer L.
  3. Alipio MM. Vitamin D Supplementation Could Possibly Improve Clinical Outcomes of Patients Infected with Coronavirus-2019 (COVID-19). [Internet]. [cited 2020 April 9]
  4. WB Grant, H Lahore, SL McDonnell et al. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020 Apr 2;12(4):988.

The author has declared no conflict of interest.