A. Kholikova*a (Prof), N. Khalimovaa (Mrs)

a Republican Specialized Scientific Practical Medical Center of Endocrinology of Public Health Ministry named by acad. Ya.Kh. Turakulov,,, Tashkent, UZBEKISTAN

* adliya2016@mail.ru

Introduction. The data indicate that prolactin (PRL) plays an important role in the pathophysiology of cognitive impairment. However, little is known about the mechanisms responsible for the influence of PRL on cognitive impairment. (1) Review of literature and meta -analysis show that serum prolactin levels in patients with Alzheimer's disease vary depending on various conditions (for example, the stage of the disease and treatment) (2)

Observation. We were examined during 2021-2022 55 women of fertile age (from 18 to 45 years). Patients had hyperprolactinemia: 1 group - patients with physiological hyperprolactinemia - 27 patients, 2 groups - patients with manifest hypothyroidism - 28 patients. The control group consisted of 20 healthy persons of a similar age and gender.

It was found that the worst results were identified in the 2nd group, which noted a significant decrease in indicators of short-term and long-term auditory memory, attention, thinking, praxis, etc.

Discussion PRL has a neuroprotective effect, improves memory, cognitive functions and ability to teach, and also has immunomodulating and antioxidant properties. At the same time, hyperprolactinemia contributes to a reliable decrease in cognitive function.


  1. Hai Duc Nguyen, Hojin Oh, Byung Pal Yu, Ngoc Minh Hong Hoang, Won Hee Jo, Hae Young Chung, Min-Sun KimAssociations between prolactin, diabetes and cognitive impairment: a literature review Neuroendocrinology2021 Dec 28. doi: 10.1159/000521653 . Online Ahead of Print
  2. Indowel HD, YU BP, Hoang NHM, JO WH, Young Chung H, KIM MS. Prolactin and Its Altern Action in Alzheimer’s Disease and Parkinson’s Disease. Neurendocrinology. 2021. Epub Ahead of Print.

The author has declared no conflict of interest.