Clinical characterization of insulin resistance in patients with different pituitary adenomas

Y. Juraeva*^a (Dr)

^a Republican Scientific and Practical Medical Center of Endocrinology, Tashkent, UZBEKISTAN

* bella_swon_92@mail.ru

Introduction.Non-invasive diagnosis of Turkish volumetric diseases

saddles are relevant in both neuroendocrinology and radiology, allowing

perform timely diagnosis of diseases in the early stages of development.

Materials and methods. Analyzed the medical history of 48 patients with

various pituitary adenomas treated at the Endocrinology Center (Department

neuroendocrinology) from 2019 to 2021(3 years), of which 15 are men(28.4%) and 33

women (71.6%). The mean age of male patients was 37.2years, and that of

women - 34.5 years. The duration of the disease ranged from 1 to 29years.Patients were divided into four groups according to etiology of disease. The first group - patients with Cushing's disease - 33(40.7%),the second group - with non-functioning pituitary adenoma (NFPA)-43(53%),the third group - with prolactinoma-4(4.9%) and the fourth group with acromegaly - 1

(1,2 %). All patients underwent clinical examination, including hormonal

examination, pituitary and adrenal gland imaging(computer (CT) and

magnetic resonance imaging (MRI)), vision tests, densitometry, etc. From

six of them (7.4%) underwent radiation therapy, 2 patients (2.4%)underwent

transfenoidal surgery (TSS) and eleven patients(13.5%) performed

adrenalectomy.

Results.CT and MRI of the pituitary gland revealed in 61 patients

(75.3%)and macroadenoma was detected in 20 cases(24.6%).

Analysis of disease history showed that among the first signs of manifestation

had headache in 37 patients (45.7%), hypertension in 7 patients

(8.6%), excessive sweet cravings in 5 patients(6.2%),heart pain in 4patients

(4.9%), dysmenorrhea in 4 patients(4.9%), visual impairment in 2patients(2.4%),

amenorrhea in 1 patient(1.2%) and infertility in 1 patient(1.2%).

Discussion.Retrospective analysis of patients with different pituitary adenomas

showed that more often the manifestation of the disease was headache(45.7%),

hypertension(8.6%),excessive sweet cravings(6.2%) and dysmenorrhea(4.9%).

Less frequent presentation of the disease was vision problems(2.4%)

and amenorrhea(1.2%).Of the risk factors for the disease, the most common were acute

viral infection(45.7%) and hepatitis(18.5%).

The author has declared no conflict of interest.