Gonadotropic function of patients with inactive pituitary adenoma (IPA)
D. Holova*a (Dr)
a Republican Specialized Scientific and Practical Medical Center of Endocrinology, Tashkent, UZBEKISTAN
The aim is to study gonadotropic pituitary function in patients with IPA.
Technique. 30 women aged 20 to 74 years were examined.
Results obtained. 11/30 of the women surveyed at the time of the survey were of menopausal age (over 50 years). In 6 (54.5%) of 11 of these women, decreased levels of gonadotropins were found to be inconsistent with postmenopausal age and low estradiol (E) concentration, which made it possible to diagnose secondary hypogonadism. In 4 women, gonadotropin levels were reduced, but the E2 concentration was within normal values. When analyzing the state of the sexual system in 19 women with IPA up to the age of 50: 1) patients with oligomenorrhea - 32%, 2) patients with secondary amenorrhea (53%) and low E2 concentration were identified. 3) 3 patients with preserved menstrual cycle and no changes in pelvic organs on ultrasound (15%), but 2 of them had increased E2 and T concentrations, and one showed hirsutism. The value of the LH/FSH ratio in patients with polycystic and without polycystic ovaries did not significantly differ: respectively 27 ± 1.4 and 2.47 ± 1.3 (p > 0.05).
Conclusions. Thus, women in the age group gpynne under 50 years with IPA by sexual status at the time of diagnosis were represented by three groups: with a normal sexual gland condition (15%); PCOS (26%); with hypogonadotropic hypogonadism (63%). Postmenopausal women - in two groups: with a normal state of the sexual system (45%) and with secondary hypogonadism (55%). In 42% of women, galactorrhea-amenorrhea is detected in combination with moderate hyperprolactinemia.
The author has declared no conflict of interest.